Jan 26, 2011 DMG and it’s use in the treatment of Autism Spectrum Disorders. DMG is Dimethylglycine (Pangamic Acid), it is an amino acid that is found in some foods naturally such as red meat, some grains and legumes. We currently have no information for DIMETHYLGLYCINE (DMG) Interactions. Dosing The appropriate dose of dimethylglycine depends on several factors such as the user's age, health, and several other.
DMG supplement sublingual 100 mg, 125 mg 500 mg benefit side effects Dimethylglycine, dosage, tablets, latest information by Ray Sahelian, M.D.
December 22 2017
If you find the field of mind-boosting pills, sex nutrients, and anti-aging interesting, you will certainly want to learn more about DMG (dimethylglycine), TMG (trimethylglycine), and methyl donors. Unless your major is college was chemistry, chances are you don’t remember learning about DMG or methyl donors. A methyl donor is simply any substance that can transfer a methyl group [a carbon atom attached to three hydrogen atoms (CH3)] to another substance. Methylation is a biochemical process that is essential to life, health, and regeneration of body cells. Vitamins, hormones, neurotransmitters, enzymes, nucleic acids (DNA and RNA), and antibodies depend on the transfer of methyl groups to complete their synthesis. Scientists suspect that proper methylation of DNA may prevent the expression of harmful genes, such as cancer genes. It’s quite likely that our body’s ability to methylate declines with age, contributing to the aging process, and therefore supplementation may well be beneficial. The research in this area is still very early and no firm answers are yet available.
To study the effectiveness of dimethylglycine on oxygen consumption (VO (2)) in children with Saguenay-Lac-Saint-Jean cytochrome-c oxidase (SLSJ-COX) deficiency. 5 children with SLSJ-COX deficiency, who were stable and old enough to comply with VO (2) measurement, were treated with placebo. Children need proportionately less TMG than adults, depending on their size and weight. Babies usually do not need it. Older children often need about 250-500 mg daily. TMG is available in a liquid and powder or crystals, and this may be easier to give to children. TMG tastes sweet, so it may be possible to just add it to children’s food. DMG and TMG help with methylation. With 90% of our kids on the autism spectrum having issues with methylation, which usually result in speech or sensory processing issues, DMG and TMG are great supplements to try. Especially since they have been reported to have a 50% success rate for ASD kids. (read about that here).
Now Foods, DMG, 125 mg, 100 Capsules
Purchase DMG supplement 100 mg pills, 60 Tablets - Source Naturals
Buy DMG 100 or 125 mg from NOW Foods or Source Naturals or try Mind Power Rx
| Supplement Facts | ||
| Serving Size: 1 Capsule | ||
| Amount Per Serving | % Daily Value | |
| N, N-Dimethyl Glycine (DMG) (from N, N-Dimethyl Glycine HCI) | 125 mg | * |
| * Daily Value not established. | ||
Dmg Or Tmg For Child Use
Suggested Use, dosage, how much to take: one 100 mg DMG tablet daily, or as recommended by your health care professional.
Some people may require higher dosages such as 125 mg or 200mg but we do not see the need to take 500 mg or more.
N, N-dimethylglycine, is a nutrient common to many grains and meat.
Serving Size 1 Tablet
DMG - 125 mg
(N,N-Dimethylglycine HCI)
Purchase DMG supplement pills
Mind Power Rx
This natural herbal and nutritional mind enhancer is an effective cognitive formula. It combines a delicate balance of brain circulation agents and neurotransmitter precursors with powerful natural brain chemicals that support:
Memory
Mental clarity
Concentration
Alertness and Focus
The herbs are Ashwagandha, Bacopa, Fo-Ti, Ginkgo biloba extract, Ginseng, Mucuna pruriens, Reishi, and Rhodiola. The nutrients and vitamins in Mind Power Rx include Acetyl-l-carnitine, Carnitine nutrient, Carnosine, Choline, DMAE, Inositol, Methylcobalamin, Pantothenic acid, Trimethylglycine, Tyrosine, and Vinpocetine. Mind Power Rx has TMG, but not DMG. Mind power Rx does not have galantamine or the club moss extract juperzine A.
DMG and other methyl donors, DMG vs TMG
Some nutrients considered to be methyl donors include DMG, TMG, SAM-e, and DMAE. Two of the B vitamins, folic acid and B12, are also considered methyl donors. Methyl donors help in the production of several brain chemicals and hence have an influence on sexual enjoyment, mood, energy, wellbeing, alertness, concentration, and visual clarity.
DMG (dimethylglycine) is basically the amino acid glycine attached to two methyl groups. It is a normal physiologically active nutrient found in low levels in such foods as cereal grains, liver, and beans. Humans also naturally produce DMG in small amounts. As a nutritional supplement, it acts as a building block for the synthesis of many important substances such as choline, SAM-e, the amino acid methionine, several hormones, neurotransmitters, and DNA.
TMG (trimethylglycine), also known as betaine, is basically the amino acid glycine attached to three methyl groups. Simply, TMG has one more methyl group than DMG.
I am wondering which has the more benefits as far as energy go, DMG vs TMG? Also, are they to be taken with food or without for max benefits?
DMG is usually available under the tongue and works quicker. They both can be taken with or without food. TMG usually provides more energy but each person is unique in their response.
Side effects on high dosage
High dosages repeated over several days could cause irritability, insomnia, restlessness, and heart beating faster or heart rhythm disturbances, therefore it is best to use the lowest dosage that works.
Q. I just purchased Aangamik DMG 125 mg sublingual tablets. In reading side effects and benefits etc I saw a study done on people with cardio vascular problems which I am told I have. I have two stents put in due to blocked arteries several years ago. Testing since has shown no further problems. Is this a good thing for this type of problem or a bad thing.
A. It is probably best to use a third or so of the pill to see if any changes occur to heart rate and please seek advice from your doctor, also.
Research with DMG supplement
Small studies have found that DMG may help boost some aspects of the immune system. Studies using it for autism have generally not found it to be helpful although there are some anecdotal reports of parents noticing that their autistic children improved by taking these pills.
Not of any benefit for autism
A double-blind, placebo-controlled, crossover pilot trial of low dose dimethylglycine in patients with autistic disorder.
J Autism Dev Disord. 1999.
As the treatability of the syndrome of autism becomes more possible there is a great deal more interest in the effectiveness of various therapies. Although the very influential nonmedical literature cited in the Autism Research Review International Newsletter finds that dimethylglycine is regarded as more effective than the usual psychopharmacologic drugs, there have been no studies of DMG using the currently accepted research methodology. We report a double-blind, placebo-controlled, crossover pilot study of low dose DMG and placebo in a sample of eight autistic males ranging in age from 4 years 5 months to 30 years 8 months, who completed the full 3 1/2-month study consisting of drug-free baseline periods at the beginning, end, and in-between two, 1-month double-blind trials in which DMG or placebo was given. Measures included the Campbell-NIMH rating scale, an experimental rating scale, and an individualized scale created for each child. Analysis of all three scales revealed no statistically significant differences, and parent reports were equally distributed. The major methodologic weaknesses of the study are thought to be the low dosage of DMG and the small sample size.
Heart disease
Arterioscler Thromb Vasc Biol. 2013. Plasma dimethylglycine and risk of incident acute myocardial infarction in patients with stable angina pectoris. Dimethylglycine is linked to lipid metabolism, and increased plasma levels may be associated with adverse prognosis in patients with coronary artery disease. We evaluated the relationship between plasma dimethylglycine and risk of incident acute myocardial infarction in a large prospective cohort of patients with stable angina pectoris, of whom approximately two thirds were participants in a B-vitamin intervention trial. Model discrimination and reclassification when adding plasma dimethylglycine to established risk factors were obtained. We also explored temporal changes and the test-retest reliability of plasma dimethylglycine. Four thousand one hundred fifty patients (72% men; median age 62 years) were included. Plasma dimethylglycine was associated with several traditional coronary artery disease risk factors. During a median follow-up of 4.6 years, 343 (8%) patients experienced an acute myocardial infarction. Plasma DMG is independently related to incident acute myocardial infarction and enhances risk prediction in patients with stable angina pectoris. Our results motivate further studies on the relationship between 1-carbon metabolism and atherothrombosis. A potential interplay with lipid and energy metabolism merits particular attention.
Q. On your article on DMG (Dimetylglycine), the study on heart disease says that it is linked with increased risk of myocardial infarction risk. Can you elaborate on this? It seems to suggest that the higher levels of DMG are dangerous, and increases the risk of heart attacks. Can you help me understand?
A. I have only seen one study regarding this association and I do not know what to make of it. As to supplementation with this nutrient, I do not see any problems or harm when it is used occasionally.
Multiple sclerosis
What is the correct dosage for DMG on MS and where can I get those pills?
I have not seen such research regarding the use of DMG supplements for patients with multiple sclerosis.
Seizures and epilepsy
My vet has prescribed DMG 100 to 125 mg for my dog who has had seizures in the past. I don't see anywhere on your site where it is mentioned for dogs or seizures. Is there any research to show that it helps with seizures?
One study in humans from 1989 did not show any benefits.
N,N dimethylglycine and epilepsy.
Epilepsia. 1989. Department of Neuroscience, University of North Dakota School of Medicine, Fargo.
Nineteen institutionalized patients with frequent seizures (group average two to three per day; seizure types--generalized, akinetic / myoclonic), were treated randomly with either placebo or N,N dimethylglycine DMG for 28 days. Dosage was 300 mg/day for the first 14 days and then 600 mg/day. No differences in seizure frequency were noted between placebo and DMG or between baseline and test conditions.
DMG Research studies
DMG Dimethylglycine supplementation does not affect plasma homocysteine concentrations in pre-dialysis chronic renal failure patients.
Clin Biochem. 2004.
Seven pre-dialysis chronic renal failure patients consumed 400 mg of DMG or placebo daily for 28 days. Fasting blood samples and 12-h urine samples were collected at baseline and at the end of each treatment period for analysis. No significant differences were observed in plasma homocysteine, glycine betaine and methionine concentrations between DMG and placebo treatments. Daily supplementation with DMG does not affect plasma homocysteine.
The effect of short-term dimethylglycine treatment on oxygen consumption in cytochrome oxidase deficiency: a double-blind randomized crossover clinical trial.
J Pediatrics. 2003.
To study the effectiveness of dimethylglycine on oxygen consumption (VO(2)) in children with Saguenay-Lac-Saint-Jean cytochrome-c oxidase (SLSJ-COX) deficiency. 5 children with SLSJ-COX deficiency, who were stable and old enough to comply with VO(2) measurement, were treated with placebo or DMG for 3 days, and with the alternate treatment after a 2-week washout period. Dietary caloric intake was calculated for 3 days before each measurement. Mean caloric intakes per day were 1562 and 1342 kcal x m(-2) before and during placebo, 1,336 and 1,380 before and during DMG, respectively. DMG was well tolerated and, in all cases, resulted in markedly increased blood DMG levels. Mean VO(2) was lower after administration of either DMG or placebo, but neither difference was statistically significant. There was no detectable effect of DMG treatment on blood levels of lactate, pyruvate, bicarbonate, or pH. This study suggests that treatment with DMG does not substantially change oxygen consumption in children with SLSJ-COX deficiency.
Dimethylglycine is an anti-stress nutrient with antioxidant properties. Recently, studies have implicated the generation of oxygen-derived free radicals and lipid peroxidation as one of the mechanisms in the pathogenesis of gastric ulcer. The results suggest that the gastroprotective effect of DMG could be mediated by its free radical scavenging activity and cytoprotection of gastric mucosa
Testimonial
I took 1,400 mg by mistake (misread the directions). The most amazing thing happened. I built and installed a wall to wall laundry shelf, organized a laundry room and painted the room in one day. The reason why this is amazing is because I have been in a couple of car accidents and suffered concussions. My brain has never been the same since. My typical day starts out with my hand on my cheek wondering what I am supposed to do. Literally, I have to figure out what to do and how to do it, such as making a cup of tea, preparing a meal, feeding my dogs. Next I have to figure out what my responsibilities are for the day and how to do them. I have notes around the house to help me know what to do next. After taking DMG I felt like a super human building that shelf and giving the laundry room an overhaul. I knew exactly what to do. I was able to determine what tools I would need. I was able to determine how to do the project and I did the project with ease, excitement and with excellence. Not once did I experience those long frustrating pauses as to what I'm supposed to do and how to accomplish something.
Emails
After reading your very interesting material about TMG and DMG supplements, I was curious as to whether those with bi-polar disease (manic depressives) should be taking this if they take Lithium. I am not bipolar, but I was just curious generally since generally they suffer manic (upper episodes) Lithium seems to level them out.
Those on Lithium who are bipolar should be cautious in using DMG or TMG since they may lead to overstimulation and potentially lead to mania.
I tried 250 mg of DMG (sublingual) and didn't feel any effect on my mood whatsoever: does it take a few days to work?
Each person is different on the required DMG dosage and how quickly they respond. Also, some people respond to one supplement while others respond to another, it is impossible to predict. Sometimes it takes a few days to notice an effect.
A friend gave me a few foils of DMG spills while I was in the mountains 9200 feet and she said it was good for altitude sickness. It did cut back on the headaches. I am trying to find out about this supplement. the foil has no brand name just DMG on it lot # 39056 she said you can get DMG supplements at any health food store. If it helped altitude headaches would it help migraines?
We are not aware of studies regarding the role of DMG supplements on altitude sickness or migraine. If your doctor approves, it may be worth a try.
I am a supplement buyer for a natural foods store in Delaware. I have taken a sublingual form of DMG is that the best way to absorb it? Like vitamin B12? Is it even absorbable in capsule or tablet form. Is there a good source for information as to the best form of supplements and how to best take them?
There is very little human research done with DMG supplements and therefore it is difficult to know the best way to absorb DMG. It does appear that sublingual DMG works well and for the time being this is a good option.
I am interested in both DMG and TMG (Trimethylglycine) but I don't know which is the best to imitate the effects of Sam-E which really worked for me but I can't take it because it upsets my stomach and I can't afford it since it's so expensive. I saw on your site that TMG has one more methyl group than DMG is it still as effective as TMG in imitating Sam-E? Also, I read that you should take methionine with both TMG and DMG if you want to imitate the effect of Sam-E and also take B6, B12, and Folic acid. Before I buy either one I just want to know which one you recommend I take if I want to have the same effect of Sam-E and if I need to also take Methionine?
DMG and TMG are not as effective as SAM-e pills in terms of mood lift, but they do offer some benefits. TMG has a longer half life and lasts longer in the body and may be the preferred choice although each person needs to try on their own to see which they prefer. As to the combination with methionine, I have not seen such studies but it is worth a try in the future to see if it adds any further benefits.
I have been taking DMG and notice an energy boost and a slight mood boost (not much but a little). I also think it adds some calmness. I will be getting the TMG and methionone soon in the mail and will let you know how it works.
Adding supplements is the next reasonable step toward improving your child’s health and function. The following supplements are so commonly lacking in our diet that it is safe and acceptable to give them to your child without testing for deficiencies. These include zinc, omega-3 fatty acids, vitamins C and D, magnesium, and,if your child is dairy-free, calcium.
The following daily doses would be appropriate the average-sized five year old child:
- zinc (15-30 mg) (Make sure that zinc is given with food.)
- cod liver oil (1-2 tsp),
- vitamin C (500mg),
- vitamin D (2000 units),
- magnesium (100-300 mg),
- and 200- 400 mg of calcium (if your child is dairy free).
Add one supplement at a time and wait for 5-7 days before adding the next supplement. Keep a notebook and record when you started the supplement and any improvements or signs of intolerance. The purpose of these supplements is to repair deficits of nutrients with widespread effects, therefore, you may notice many improvements. For example, with zinc you may see improvements in sleep, immune function skin, growth, and sometimes appetite (taste buds). Cod liver oil may improve eye contact and decrease strange eye movements, agitation or hyperactivity, and enhance skin health and immune defenses. Vitamin D has major importance in immunity, (as does vitamin C), and in addition, helps with detoxification and reduction of oxidative stress. Magnesium may prove helpful with relaxation, sound sensitivity, sleep, bowel movements (in larger doses it is a good laxative). Calcium may also be calming and is often helpful with children who press on or gouge their eyeballs. These children may require higher doses up to as much as 2000 mg per day.
Be aware when giving mineral supplements that labeling can be confusing, as the minerals are actually a salt containing two ingredients (e.g. calcium carbonate, zinc picolinate, magnesium glycinate, etc.). In each case, the second component is heavier than the mineral, and the label needs to be read carefully to obtain the correct and desired dose. For example, a bottle of calcium carbonate may read “l000 mg”. The fine print may show that 2 capsules provide 1000 mg of calcium carbonate (and may or may not tell you that calcium carbonate is 40% calcium, so that 2 capsules give you 400 mg of calcium and 600 mg of carbonate). When we speak of dosages of mineral supplements, we mean elemental minerals, or the mineral itself, and not the entire compound.
Administering Supplements
You will undoubtedly meet resistance when you decide to give your child a strange tasting powder or oil, and succeeding with some of the unpleasant tasting supplements requires ingenuity and perseverance. When Bernie Rimland (who might be called the Father of biomedical treatments for autism), was asked by a parent how to get her child to take supplements, his succinct answer was, “Who’s bigger?”. It usually requires tough love and experimentation. I also encourage parents to be honest, telling their child, “This is medicine,” which means 1) “You have to take it,” 2) “It probably tastes bad,” 3) “It’s good for a person,” and perhaps 4) “It’s the doctor’s orders, not mine, so don’t blame me, I’m sorry it tastes bad.”
The most reliable to administer supplements is with a medicine syringe, just as you would give an antibiotic. You can likewise sweeten it with juice concentrate, maple syrup, etc. If you use a syringe you’ll most likely have to train your child to accept the syringe, by repeated practice. One of our patients who had a severely restricted diet, but learned to accept the syringe, would eat soup from a syringe, but only if she was told it was medicine. Other parents have found smoothies or homemade sorbet or fruitsicles, or for the rare child who eats it, soup, to work as a vehicle to administer supplements. Failing this, several companies have formulated many of their supplements in naturally flavored, sugar free liquids or powders to make them more palatable. And some supplements such as zinc, vitamin D, magnesium, calcium, buffered vitamin C are easily concealed in juice or food. We are happy to recommend specific brands of supplements and remedies should you choose to work with us.
Introduce Probiotics and Digestive Enzymes
If your child has bowel problems of any sort, or a history of repeated infections and antibiotics, it is reasonable to offer help with probiotics and digestive enzymes. Probiotics, or beneficial bacteria for the bowel, come in a variety of forms and packages. In brief, I suggest you add a combination containing strains of Lactobacillus and Bifidus, in doses between 20 billion per day and 900 billion per day. You’ll be using capsules or powders which list dose and strains information on their label. Some children respond much better to one product than to another, and so it is worth trying one brand for a few weeks, and then switching to something different (e.g. one containing Bacillus Subtilis or Saccharomyces Boulardi), if no improvements are noted. It may be particularly beneficial to feed your child cultured foods such as coconut kefir or sauerkraut or unpasteurized pickles or other home cultured foods which contain lots of good bacteria.
In addition to probiotics, digestive enzymes may provide considerable benefit for abnormal stools, abdominal pain, food intolerance, and difficult behaviors. As with probiotics, there are a number of good products available, and it is useful to try several different preparations in order to obtain the best results. It is valuable to do a two to three week trial with at least two different preparations, including a plant based enzyme and a pancreatic (animal based) enzyme, as their effects can be quite different.
A small number of children react negatively to probiotics or to enzymes, and can’t take them (but may benefit at a later date after correcting other factors such as bacterial or fungal overgrowth).
Supplements for Specific Conditions
As you add supportive therapies, be sure to continue to reference your problem list and grading system regularly, to address the four questions posed above. Next we want to consider more selective supports, based on your child’s symptoms and diet.
Autism and related disorders are very complex and each child’s physiology is unique. While none of the below-listed interventions are dangerous, choosing the right supports and their proper sequence can get very complicated. When possible, it is best to work with us or another trained physician to guide you in the supplementation process.
Children Who Don’t Eat Meat
If she doesn’t and hasn’t eaten meat in her life, iron will be most likely deficient, and can be safely supplemented at 15-30 mg per day. (Blood testing by your physician for Fe and TIBC and/or ferritin will identify iron deficiency if present). Iron may improve energy and immune function, but can be constipating. If you are supplementing iron and/or zinc, the blood levels should be checked within 6 months, to be sure that iron or zinc levels don’t get too high, or that zinc doesn’t cause copper to drop too low. We would like to see both serum zinc and copper levels at 100 mcg/dl.
Children Who Eat Few Fruits and Vegetables
If your child eats very few fruits and vegetables, B vitamins and trace minerals (including selenium, chromium, manganese, molybdenum in particular) may be helpful. Many supplement companies make balanced trace mineral supplements which also contain 10-25 mg of zinc, thereby replacing your zinc supplement.
B Vitamins
B vitamins, while grouped as a single type of supplement, mainly because they are water soluble and work somewhat in concert, are actually very different one from another, and deserve a separate discussion. Our children are most commonly helped by methyl B12, B6, reduced folic acid (folinic acid or methyl folate), and B3. Contrary to popular opinion, it is not necessary to give all the B vitamins when supplementing, though there is often a deficiency or need for several of them which may benefit from a complete B supplement. We like to give methylB12 as the first B vitamin, preferably by injection, and have found this to be of great benefit for a significant number of children we treat.
Notable benefits in speech, understanding, sleep, behavior, mood, energy, and executive function have been noted in children with autism related issues. A small percent of children become hyperactive after methylB12, and need to have lower and/or less frequent doses or be switched to hydoxyB12. A very small number simply do not tolerate B12 at all. Please note that B12 is far more effective by injection than by oral route or lotion or nasal spray.
If your physician is willing to write a prescription for it, we can provide information regarding compounding pharmacies to assist you in getting your prescription filled. We can also assist in providing guidance about how to safely and easily give the shots (which are very nearly painless, except for the angst of the parent giving the shot). The usual starting dose is (methylB12, 25 mg/ml), 0.01 ml per 10 pounds of body weight, given by very shallow subcutaneous injection every 3 days. If your physician is not comfortable helping you with this, we can help you if your child becomes a patient of record with the Evergreen Center. If you can’t get injectable methyl B12, then by all means do a trial with oral methyl B12 (available as lollypops, lozenges, powder or pills).
Vitamin B6 in combination with magnesium has been used successfully in autism for decades, and shows benefit in around 30% of children. When effective, it seems to help make children more comfortable in their bodies, calming and improving problem- solving through communication and better access to their own resources. Starting doses of around 50 mg are commonly used, and may be increased stepwise up to maximum of 8 mg per pound. It should be combined with magnesium in the doses described above. Vitamin B6 can cause a sensory nerve problem in high doses, but there has been no demonstration of this problem in autistic children receiving these maximum doses over long periods of time. However, as always, it is essential to be gentle and observant. We don’t raise doses if we see signs of intolerance, which consist of agitation or disturbed sleep, and if these symptoms occur, it should be discontinued. A later trial may be beneficial when the digestive tract is functioning well, and when the child has a good intake of protein.
Folinic acid or methyl folate are active forms of folic acid which work together with B12 to enhance energy production and transport, neurotransmitter synthesis, myelin production, detoxification, cellular communication, immune function, gene expression and regulation. Folic acid, which is found in many supplements, but not in foods, requires activation by an enzyme which is frequently impaired in children with chronic health problems. As a consequence, it is preferable to use either folinic acid (available by prescription as Leucovorin, or over the counter) or methyl folate (available by prescription as Deplin, or over the counter). Support of the folate pathway is frequently helpful in children with autism, and is extremely safe, even at very high doses. Children may become agitated if dose is excessive. Starting with a dose of 400 mcg (0.4 mg) per day, one may raise the dose by doubling every 5-7 days, to a dose of 1600 mcg. We have found that some children need extremely high doses of 5000 to 80,000 mcg per day, due to a blockage in the mechanism for transport of folate into the nervous system. These extremely high doses are best given by prescription (Leucovorin is available in 25,000 mcg tablets, and Deplin in 15,000 mcg tablets). It is important to note that blood levels of both vitamin B12 and folic acid are a poor indicator of nutritional status, as these vitamins are critical in brain function, and blood levels correlate poorly with brain levels (due to impairments in brain uptake of these vitamins which are occur frequently in children with autism). If the blood levels are low, then the brain is likely also deficient, but is blood levels are high, this may indicate a block in brain uptake, with actual brain deficiency.
Vitamin B3 (niacinamide, also niacin, which is a form of B3 better avoided in children with autism, as it may cause intense and unpleasant flushing), has also been called the “sleep vitamin,” as it enhances serotonin and melatonin levels. Niacinamide thus may be calming, and it sometimes helps reduce stimming behaviors. It also is essential in the energy and antioxidant pathways which are so critical to healthy brain function. Niacinamide should be given with an equal or greater dosage of supplemental vitamin C (for 500 mg of B3, give at least 500 mg vitamin C). The usual doses in 40-50 pound children are 250 to 500 mg per day. In very high doses, vitamin B3 can cause liver stress, which is always associated with nausea and or decreased appetite. And so a reduction in appetite should be taken as an indication to stop B3 and/or check the ALT liver enzyme level in blood.
Though TMG, DMG, and DMAE are not officially B vitamins, they are water-soluble nutrients which are safe, occur naturally in the brain, and are often helpful in children with autism related disorders. Both TMG and DMG help improve immune function, and may improve speech, awareness, and attention. Both can cause overstimulation or agitation, and TMG is somewhat more likely to do so. If this should occur, the child will calm down to baseline within a day or two of discontinuing the supplement. Some children clearly respond better to TMG, and some to DMG, and some to the two together. For TMG, we use doses of 175 mg to start, and may move to doses as high as 1000 mg per day with further benefit. One good study used a TMG dose of 2000 mg per day without problem in any of the children. For DMG, we generally start with 125 mg per day, working up as tolerated to 500 mg or higher per day. Dr. Rimland reported that children with severe agitation or aggression have , in some cases ,responded to DMG doses of up to 2000 mg per day.
DMAE has brought improvements in disposition, behavior and language, with doses of 50 to 300 mg daily. Higher doses are safe, and could be used if the child is showing encouraging improvements on lower doses. Occasionally, children will become agitated on DMAE, and it must be discontinued.
General Comments Regarding Supplementation
It is worth commenting on the experience that children with autism may react paradoxically to almost any remedy offered. While dangerous reactions are extremely rare (except for the possibility of harm to self or others if a child becomes extremely agitated or aggressive), is not common in most parents’ experience that their child will react unpredictably to an intervention. The most common adverse reaction is agitation, which most likely reflects a discomfort he’s not able to explain. In some cases, the agitation is a sign of a healing crisis, or a healthy readjustment occurring with some resistance. Nevertheless, in all cases it is an indication to reduce the dose, or stop the remedy and provide further support to the body before offering it again. This experience is in line with the finding that children with autism are often very different from one another, so that it is not reliable to predict an effect in one child based on an effect seen in another child. We need to work with our child as an individual, while still learning from the experiences of other children.
Dmg Or Tmg For Child Health
While all of the remedies and interventions described above are safe and approved for use without prescription, we strongly encourage you to work with a physician. It is best, when possible, to establish a doctor-patient relationship with the Evergreen Center. If you do not have physical access to our center or to a physician supportive of your work with your child, please contact us for further education and support at info@childrenandautism.com.
Dmg Or Tmg For Children S
The above described remedies represent a good group of supports which should help to improve your child’s health, and may also improve many of his symptoms and problems. Autism is very complex, and there are many more interventions, sometimes including prescription medications which may be needed to make further gains. These include herbal supplements, sulfur supports (glutathione, NAC, Epsom salt baths, MSM, taurine), other vitamins (B’s, K, E, carotenoids, biopterin), amino acids, laxatives, prescription or natural antimicrobials (for parasites, yeast, bacteria) both, hormones (thyroid, cortisol, growth hormone, oxytocin, secretin), detoxification remedies (chelation, intravenous remedies, etc.), anticonvulsant medications, intestinal anti-inflammatories, and so on. As we learn more about autism, promising new remedies emerge, which are especially helpful with some of our children.